BIOAVAILABILITY OF CURCUMIN PROBLEMS AND PROMISES PDF

Ajaikumar B. Robert A. Anderson Cancer Center, Houston, Texas Received August 19, ; Revised Manuscript Received September 27, ; Accepted September 28, Abstract: Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-in? Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken.

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Corresponding author. Correspondence: Bharat B. Aggarwal, PhD. Tel: , Fax: , gro. This article has been cited by other articles in PMC. Abstract Curcumin diferuloylmethane is a yellow pigment present in the spice turmeric Curcuma longa that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6, citations.

In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed. Keywords: Curcumin, Nano-formulation, Biological availability, Metabolism, Anticancer Introduction Curcumin is the major active component of turmeric, a yellow compound originally isolated from the plant Curcuma longa.

It is a member of the curcuminoid family and has been used for centuries in traditional medicines. As a spice, it provides curry with its distinctive color and flavor. Furthermore, traditional Indian medicine has considered curcumin a drug effective for various respiratory conditions asthma, bronchial hyperactivity, and allergy as well as for other disorders including anorexia, coryza, cough, hepatic diseases, and sinusitis [ 1 , 2 ].

Extensive research over the past 30 years has shown that it plays an important role in the prevention and treatment of various pro-inflammatory chronic diseases including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and malignant diseases. How curcumin could exhibit these diverse effects has been a clandestine over the years.

However, numerous line of evidence indicates that this agent is highly pleiotropic with anti-inflammatory [ 3 ], hypoglycemic [ 4 , 5 ], antioxidant [ 6 ], wound healing [ 7 ], and antimicrobial activities [ 8 ]. It has been shown to possess chemosensitization, chemotherapeutic and radiosensitization activities as well [ 9 ]. Curcumin has been studied for its chemopreventive potential in a wide variety of cancers, in both preclinical studies and in clinical trials [ 10 ].

Many clinical trials using curcumin as a therapeutic agent are underway [ 11 ]. Because of its marvelous properties, curcumin is being marketed in several countries including the United States, India, Japan, Korea, Thailand, China, Turkey, South Africa, Nepal, and Pakistan in different form such as capsules, tablets, ointments, energy drinks, soaps, and cosmetics Fig.

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Kunnumakkara, Robert A. Newman, and Bharat B. Aggarwal Mol. Anderson Cancer Center, Houston, Texas Received August 19, ; Revised Manuscript Received September 27, ; Accepted September 28, Abstract: Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antian- giogenic activities. Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination.

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Boosting the Bioavailability of Curcumin

Mol Pharm. Epub Nov Bioavailability of curcumin: problems and promises. Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination.

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